ATG5 and Autoimmunity: However, the physiological relevance of autophagy-associated antigen presentation during negative selection remains controversial, as autoimmunity development depended on the experimental model used; athymic mice which received an Atg5-deficient thymus developed autoimmunity (204), but this was not the case in mice where Atg7 was selectively deleted in thymic epithelium using a Cre-loxP approach (206).