In spite of this, more recent studies have shown decreased inflammation, increased tissue perfusion, and improved survival with (1) late DNase treatment in cecal ligation puncture (CLP) model of murine sepsis (55), (2) concurrent DNase and tPA treatment in a rat model of myocardial ischemia (85), and (3) preemptive DNase treatment in a rat model of renal ischemia-reperfusion injury (86). This evidence concerns the gene PLAT and myocardial ischemia.