In this context, the current study was designed to evaluate the outcome of Malaria-CL infections, the CD4 and CD8 T-cell profiles as well as the Th1/Th2 cytokine levels in a co-infection murine model (BALB/c) of P. yoelii 17XNL (non-lethal) and L. amazonensis or L. braziliensis. The gene discussed is CD4; the disease is malaria.