However, our recent understanding of the involvement of IgA-coated bacteria in intestinal inflammation (Van der Waaij et al., 2004; Palm et al., 2014), as well as the number of clinical studies denoting an association between inflammatory lung disease and intestinal inflammation (Tulic et al., 2016); provides rationale for investigating the systemic immune effect of IgA-coated GIT bacteria. The gene discussed is CD79A; the disease is inflammatory response.