Based on the rationale that ACTH plays a more important role in PA than in normal subjects or those with essential hypertension, investigators in Athens compared the classical saline infusion test (SIT) to postdexamethasone SIT in 151 patients with single adrenal adenomas and detected almost double rate of aldosterone hypersecretion following dexamethasone administration (24 vs. 12%) (72). This evidence concerns the gene POMC and hypertensive disorder.