MC2R and adenoma: Using a microarray approach in 10 aldosteronomas compared with five normal adrenals and 13 cortisol-secreting adenomas, the six GCPRs with highest increase in expression included LHCGR, 5-HT4R, GnRHR, glutamate receptor metabotropic 3, endothelin receptor ETB receptors, and MC2R (92).