On the other hand, there are NDs in which PPAR gamma is downregulated while the Wnt/beta-catenin pathway is upregulated, such as in amyotrophic lateral sclerosis (ALS), Huntington’s disease, Parkinson’s disease, multiple sclerosis, and Friedreich’s ataxia. The gene discussed is CTNNB1; the disease is amyotrophic lateral sclerosis.