In a study on osteosarcoma, the inhibition of cancer cell proliferation by icariside II was associated with its ability to inactivate epidermal growth factor receptor (EGFR)/mammalian target of rapamycin (mTOR) pathway, showing that icariside II might target mTOR, the master switch of tumor cell proliferation (Geng et al., 2014). Here, EGFR is linked to osteosarcoma.