BCL2 and colonic neoplasm: Puerarin may act as a chemopreventive and/or chemotherapeutic agent in colon cancer cells HT-29 and hepatocellular carcinoma cell SMMC-7721 by reducing cell viability and inducing apoptosis through bcl-2/caspase3 or mitochondria-dependent pathway (Yu and Li, 2006; Zhang et al., 2014).