S1PR2 and chronic myelogenous leukemia, BCR-ABL1 positive: In chronic myeloid leukemia, S1P2 enhanced Bcr–Abl1 stability via inhibition of protein phosphatase-2a, and inhibition of SphK1/S1P2 restored the chemosensitivity of leukemia allografts in mice (Salas et al., 2011).