Thiazolidinediones, which are PPAR-γ agonists, have been used for years as insulin sensitizers in diabetes mellitus type 2, but they have been gradually removed from the market because of hepatotoxicity, increased cardiovascular risk, or increased occurrence of bladder cancer (Yki-Jarvinen, 2004; Cariou et al., 2012). Here, INS is linked to diabetes mellitus.