However, recent studies on the role of S1P2 in anaphylaxis yielded contradictory results (Table 1): One group observed that JTE-013 and S1P2 knockout attenuated the severity of anaphylaxis and reduced circulating histamine levels as well as pulmonary edema and allergic lung infiltration in a mouse model of immunoglobulin E (IgE)/antigen-triggered anaphylaxis (Oskeritzian et al., 2010, 2015). The gene discussed is S1PR2; the disease is edema.