However, several reports underline a rather pro-cancerous role of S1P2 (Table 1): although S1P2 inhibited migration of glioma cells, it enhanced the expression of the matricellular protein CCN1/Cyr61 and stimulated glioma cell invasiveness and adhesion (Young and van Brocklyn, 2007). The gene discussed is S1PR2; the disease is glioma.