Furthermore, the dorsomorphin derivative LDN-193189, antagonized inflammatory induction of hepcidin in cells and mitigated anemia in rat (Theurl et al., 2011) and mouse (Steinbicker et al., 2011; Mayeur et al., 2015) models of ACD, and in a rat model of kidney disease (Sun et al., 2013). This evidence concerns the gene HAMP and anemia (phenotype).