Yet, few studies have investigated whether ApoE genotype differentially moderates the direct relationship between cognitive performance and CBF (Bangen et al., 2012; Wierenga et al., 2013) and to our knowledge, no study has looked directly at this relationship using a voxel-wise approach to determine if regionally-specific associations between cognitive performance and CBF exist and are differentially affected by AD risk. Here, APOE is linked to Alzheimer disease.