Previous studies in adult SF-1 KO and in VMH-specific SF-1 KO showed that structural changes in the VMH could result in impaired social behaviors, such as anxiety, aggression, and female sexual behavior (Grgurevic et al., 2008, 2012; Zhao et al., 2008), in addition to impairment in energy balance regulation (Majdic et al., 2002). The gene discussed is SF1; the disease is Anxiety.