TNF and early-onset autosomal dominant Alzheimer disease: TNF-α has been implicated in the pathogenesis of a wide number of neurological disorders that develop both acutely, as in traumatic brain injury and stroke, and chronically, as in Alzheimer’s disease and Parkinson’s disease (McCoy and Tansey, 2008; Tobinick and Gross, 2008; Tuttolomondo et al., 2008).