RELN and familial pancreatic carcinoma: Reelin-responsive cells outside the central nervous system remain mostly elusive, although significant amounts of Reelin are detected in plasma and various non-neuronal tissues (Ikeda and Terashima, 1997; Smalheiser et al., 2000; Kobold et al., 2002; Lugli et al., 2003; Botella-Lopez et al., 2008), and functional effects of Reelin on blood cells such as platelets (Tseng et al., 2014), endothelial cells (Ding et al., 2016), or pancreatic cancer cell lines (Sato et al., 2006) have been described.