TP53 and neoplasm: It has many different functions that contribute to its ability to suppress metastasis and tumor growth, which include its ability to upregulate p53 upon oncogene expression (Raveh et al., 2001), to induce apoptosis in response to loss of matrix attachment and cytotoxic cytokines such as TNF-α (Inbal et al., 1997; Wang et al., 2002), to activate pyruvate kinase M’s glycolytic function (Mor et al., 2012), and to arrest cell motility and metastasis (Kuo et al., 2006).