Further it has been reported that DAPK1 phosphorylates tau protein at Ser262 (pS262) in cortical neurons of stroke mice and either blocking DAPK1-tau interaction by systematic application of a membrane permeable peptide or genetic deletion of kinase domain (KD) in mice (DAPK1-KD−/−) protects spine damage and improves neurological functions against stroke insults. The gene discussed is DAPK1; the disease is Stroke.