For example, whilst Bos-Veneman et al. (2011) observed that TS children were characterized by decreased levels of IgG3 (Bos-Veneman et al., 2011), Kawikova et al. (2007) observed reduced concentrations of regulatory T cells in TS patients compared to controls (Kawikova et al., 2007). This evidence concerns the gene IGHG3 and Timothy syndrome.