It is well accepted that oxidative stress contributes to PD, and there is interest in understanding how oxidative stress is exacerbated by the emerging regulators, microRNAs (miRNAs) via contributing to the pathological processes which are responsible for oxidative stress like mitochondrial dysfunction (Subramaniam and Chesselet, 2013), α-synuclein aggregation (Hsu et al., 2000), neuroinflammation (Tansey et al., 2007), and dysregulation of the endogenous antioxidant system (Buendia et al., 2016). Here, SNCA is linked to Parkinson disease.