Amongst all the compounds tested, MTDL ASS234 particularly has emerged as an interesting lead compound for the design of novel MTDL with a good MAO/AChE inhibitory potency, a significant activity against amyloid aggregation, neuroprotective and anti-apoptotic properties, as well as potent antioxidant capacities, so may have a potential disease-modifying role in the treatment of AD. Here, ACHE is linked to Alzheimer disease.