Finally, plasma levels of anti-ClpB IgG cross-reactive with α-MSH were increased in patients with eating disorders, and several significant correlations were found between EDI-2 scores and anti-ClpB IgG and IgM levels in AN patients (Tennoune et al., 2014), similar to previous findings with anti-α-MSH reactive Igs (Fetissov et al., 2005). This evidence concerns the gene CUBN and eating disorder.