C3AR1 and asthma: Figure 3 illustrates the lung eQTL rs17801353-C3AR1 in Laval as well as replications in Groningen and UBC. rs17801353 is located in an intron of FOXJ2 7.6 kb downstream of C3AR1. The eQTL was significant and showed the same direction of effect in the two replication cohorts (P < 0.05). The asthma risk allele for rs17801353 in the QCCCAC corresponds to the allele associated with higher mRNA expression levels for C3AR1, suggesting that upregulation of this gene may increase asthma susceptibility. The most significant lung eQTL (P < 10E − 5) are shown in Supplementary Table 3.