The asthma risk allele for rs6934016 (A) identified by individual genotyping corresponds to the allele in LD with SNP rs2295190 (T) producing a missense change. SYNE1 has never been associated with asthma, but two intronic SNPs of this gene have been associated with forced vital capacity according to the Phenotype-Genotype Integrator (PheGenI) [33]. SYNE1 is expressed in skeletal and smooth muscle, particularly in the sarcomeres [34]. The gene discussed is SYNE1; the disease is asthma.