The combined analysis of VEGF with CA 15-3 or all tested parameters showed an increase in AUC values (0.908; p < 0.001 in both cases), but the maximum range in stage IV of BC was obtained for the combination of M-SCF and CA 15-3 (0.921; p < 0.001) (Figure 5). The gene discussed is VEGFA; the disease is breast cancer.