We noticed that the VEGF area under the ROC curve (0.729) in the total group of breast cancer was higher than the area of CA 15-3 (0.698) and M-CSF (0.645), statistically significantly larger in comparison to AUC = 0.5, borderline of the diagnostic usefulness of the test (p < 0.001 in all cases). The gene discussed is CSF1; the disease is breast cancer.