In the present study, we first investigated the expression of Notch3 and S6K in human ovarian epithelial cancer, to verify their expression related to clinicopathological features and prognosis in human ovarian epithelial cancer and to further evaluate their potential value as biological markers of aggressiveness in ovarian cancer, with the goal of improving the management of ovarian cancer patients. This evidence concerns the gene NOTCH3 and ovarian carcinoma.