Similar to Notch3 expression, the expression of pS6 in ovarian epithelial cancer (108/120, 90%) was significantly higher than in normal ovarian tissue (5/30, 16.7%) (p < 0.01) and ovarian cystadenoma (23/30, 76.7%) (p < 0.01), and a significant increase in pS6 was observed in ovarian cystadenoma compared to normal ovarian tissue (p < 0.01). This evidence concerns the gene NOTCH3 and ovarian carcinoma.