NOTCH3 and cystadenoma: In our study, Notch3 expression in ovarian epithelial cancer was significantly higher than in benign cystadenoma and normal ovarian tissues (p < 0.01, Table 1) and was associated with clinical stage, pathological grading, histologic type, lymph node metastasis, and ascites (p < 0.01 or p < 0.05), suggesting that the Notch signaling pathway is in an activated state and probably plays an important role in the development of ovarian epithelial cancer [1, 8, 12, 13, 15, 16].