Lung inflammation involves the activation of inflammatory cells, such as macrophages, lymphocytes, neutrophils, and eosinophils, which is a source of different kinds of inflammatory mediators such as histamine, tumor necrosis factor (TNF-α), interleukins, IL-1β, IL-4, IL-5, and IL-6, prostaglandins, leukotrienes, and nitric oxide. The gene discussed is TNF; the disease is inflammation.