The administration of wogonin (35), a flavone derived from a plant called Scutellariae radix, reduced the total IgE and ovalbumin specific IgE levels compared with the ovalbumin challenged group [68]. Astragalus membranaceus, a traditional Chinese herb, decreases airway allergic responses, including specific IgE, eosinophilia, lymphocyte infiltration, and airway inflammation, modulates Th1/2 immune balance, and activates PPAR in a murine asthma model [69]. The gene discussed is IGHE; the disease is asthma.