For example, in C5- and C6-deficient mice, it has beenfound that the MAC contributes to multiple diseases, including seizures in anexperimental cerebral malaria model49, brain ischemia50, renal ischemia/reperfusion injury51, atherosclerosis52, and Ab-mediated antiphospholipid syndrome (APS)53.Using CD59-deficient mice, we54, 55, 56 and others52, 57, 58 have demonstrated that the MAC contributes to thedevelopment of atherosclerosis and aneurysms. The gene discussed is CD59; the disease is atherosclerosis.