IGF1R and malignant colon neoplasm: Such abnormal expression can regulate cell proliferation, cell growth, clone formation, apoptosis, cell cycle, invasion, and migration by targeting lots of genes such as metastasis-associated in colon cancer-1, insulin-like growth factor 1 receptor, DNA methyltranferase 3A, paxillin, toll-like receptor 2, fascin-1, and KRAS16, 17, 18, 20, 21, 23, 24, 25.