In contrast to its restricted distribution in normal healthy tissue, Kv10.1 is significantly overexpressed in many tumour cell lines and in a variety of solid tumours from different histological origins such as breast, colon or cervix (Hemmerlein et al. 2006; Mello de Queiroz et al. 2006; Ding et al. 2007a, b). Here, KCNH1 is linked to neoplasm.