Knockdown or blocking of Kv10.1 with siRNA or a monoclonal antibody selectively inhibiting Kv10.1-mediated potassium currents reduced the proliferation of cancer cell lines and tumour growth in in vivo models (Weber et al. 2006; Gomez-Varela et al. 2007; Downie et al. 2008). Here, KCNH1 is linked to neoplasm.