TP53 and cancer: In this study, we confirmed that CD317-silencing increased the susceptibility of tumor calls to apoptosis, and importantly, this effect of CD317-silencing was only observed in serum-deprived cells, implying that gene interference targeting CD317 might be used as a combined approach for the antiangiogenic tumor therapies; 2) One of the major challenges in cancer therapy is that many tumor cells carry mutations in key apoptotic genes such as p53, bcl family proteins or those affecting caspase signaling, thus making traditional chemotherapeutic agents ineffective.