Various studies linked statin effects with the pathogenesis of pulmonary hypertension and various biomarkers27, through analyzing the relation between statins, endothelin-1 and PAH28, 29, statins, asymmetric dimethylarginine and PAH30, 31, 32, statins, D-dimers and PAH33, 34, statins, von Willebrand factor antigen and PAH35, 36 or fibrinogen and PAH37, 38. Here, EDN1 is linked to pulmonary arterial hypertension.