To find more evidence of enhanced cardiac hypertrophy and myocardial fibrosis inoffspring of LPS-treated mothers after ISO treatment, we also measured the geneexpressions that related to cardiac hypertrophy and myocardial fibrosis, such asα-myosin heavy chain (α-MHC),β-myosin heavy chain (β-MHC), atrial natriureticpeptide (ANP), brain natriuretic peptide (BNP), collagen type Ialpha 1 (Col1a1), collagen type III alpha 1 (Col3a1). The gene discussed is COL1A1; the disease is Myocardial fibrosis.