In populations where the -94del allele was identified to increase cancer risk, a plausible interpretation for such observation could be that the p50 protein lacks the C-terminal transactivation domain and may form inhibitory homo-dimers, which can serve as a role in repressing pro-inflammatory genes and then resulting in decreased levels of p50/p50 repressive homo-dimers in -94 del allele carriers60, 61. The gene discussed is NFKB1; the disease is cancer.