To investigate the potential relationship between antibodies specifically targeting epitopes of OxLDL and NAFLD, IgM and IgG antibody titers against MDA, MAA (an immunodominant advanced MDA-lysine adduct), P1 (a highly specific peptide mimotope of MAA [10]), Cu-OxLDL, and PC-BSA were measured in the plasma of patients with NAFLD (n = 71) and control participants with confirmed absence of steatosis (n = 68). Here, CD40LG is linked to metabolic dysfunction-associated steatotic liver disease.