HLA-G and myeloid sarcoma: HLA-G has an important role in MS: (i) cerebrospinal fluid (CSF) levels and the intrathecal synthesis of sHLA-G are higher in MS patients in comparison with controls and are associated with clinical and radiological evidence of disease remission (ii) elevated sHLA-G concentrations in CSF correlated with the presence of an anti-inflammatory and pro-apoptotic intrathecal microenvironment, (iii) HLA-G expression is high within and around MS lesions and (iv) HLA-G + regulatory T cells highly represented in brain lesions of MS patients [8].