Consistently, expression of T-cell lymphoma invasion and metastasis-1 (Tiam1), a Rac-specific GEF, or constitutively active Rac1 in the renal cell carcinoma cell line ClearCa-28 inhibits cell migration, via enhancing E-cadherin-mediated adhesions. The gene discussed is TIAM1; the disease is hereditary clear cell renal cell carcinoma.