KCNN2 and Schnyder corneal dystrophy: A single miR can regulate multiple genes, and a single gene can be regulated by multiple miRs.[59–61] It is possible that some of the polymorphisms in the LD block that is associated with our tag SNPs (rs13184658 and rs10076582) are true disease-associated SNPs and are involved in the mechanism of SCD at the epigenetic level mediated by miRs, affecting either KCNN2 or other related genes’ activities.