Narcolepsy–cataplexy associated with decreased CSF hypocretin-1 (167 pg/mL) was reported previously in a 23-year-old man who presented a large hypothalamic stroke following the removal of a craniopharyngioma at the posterior hypothalamus.[10] However, whether hypocretin is involved in hypersomnia in AOP infarction has not been well studied. This evidence concerns the gene HCRT and hypersomnia.