Although likely underestimated, the prevalence of AOP is only in 0.1% to 2% of all strokes and 4% to 18% of thalamic strokes.[5,6] Our primary findings are that the CSF hypocretin-1 levels were not reduced in the patients with BPT-MI but were reduced in the patients with BPT+RMI, who likely had ischemic lesions extending to the lateral hypothalamus. This evidence concerns the gene HCRT and stroke disorder.