To the best of our knowledge, this is the first study to demonstrate an association of higher serum T-IgE with the presence and severity of bronchiectasis in moderate–severe COPD, which implies that newer approaches targeting IgE production or action (e.g., anti-IgE antibodies) might be of therapeutic potential in attenuating symptoms and outcomes associated with bronchiectasis in a subset of patients with COPD. The gene discussed is IGHE; the disease is bronchiectasis.