Baseline ApoE-/- mice after WD had a significantly increased number of Ly6Chi monocytes (2.4E8 ±0.7E8, P<0.05 to all recipients) as expected from their hypercholesterolemia [39], but no differences were observed in Ly6Chi monocytes across the normolipidemic recipient WT groups. The gene discussed is APOE; the disease is familial hypercholesterolemia.