The expression of IL1Α, IL1Β, CXCL1, CXCL9, CCL2, CCL22, RNASE7, SLPI, WFDC12, AREG, EREG and HBEGF was increased from about 1.4- to 8-fold on average in the lesional ichthyosis skin. This evidence concerns the gene HBEGF and ichthyosis.