In order to investigate if 11KT and 11KDHT demonstrate androgenic activity on endogenous AR-regulated genes, the mRNA expression levels of KLK3 (NM_001030047), FKBP5 (NM_001145775) and TMPRSS2 (NM_001135099) were assessed in two androgen dependent prostate cancer cell lines, LNCaP and VCaP. The gene discussed is TMPRSS2; the disease is prostate carcinoma.