IGHE and Increased total eosinophil count: Although dual inhibitors of PI3Kγ and δ are considered as promising agents in the treatment of asthma, mice constitutively lacking PI3Kγ and -δ enzymatic activity suffer from eosinophilic inflammation in mucosal tissues and IgE hyperproduction [23], suggesting that pharmacological long-term inhibition of PI3Kγ and -δ may eventually aggravate asthma by inducing eosinophilia.