The release of TNF (182 [104–349] and 232 [109–564] pg/ml, respectively) by PBMCs from the patients who formed immune (BCG) and innate (CB) granulomas was significantly (p < 0.05) higher than that of PBMCs from patients unable to form immune and innate granulomas (36 [23–46] and 38 [18–50] pg/ml, respectively) (Fig 3B). This evidence concerns the gene TNF and Granuloma.