Considering data achieved from experimental CDV infection and lesion development in dogs, the accumulation of ECM molecules like type I and IV collagen and fibronectin as well as the downregulation of phosphacan were most prominent in subacute and chronic lesions which occur as early as 24–32 days post infection (subacute non-inflammatory) and after a minimum of 29–63 days post infection (inflammatory subacute and chronic lesions) [93–98]. The gene discussed is PTPRZ1; the disease is infection.