In particular, some members of the TNF superfamily promote Pi-induced VSMC osteogenic transition and subsequent calcification.7 TNF-like weak inducer of apoptosis (TWEAK) is a TNF superfamily cytokine that recently emerged as a new biomarker for diagnosis and prognosis in cardiovascular diseases.8 Membrane-bound TWEAK can be processed by furin to soluble TWEAK (sTWEAK).9 TWEAK binding to its receptor fibroblast growth factor-inducible molecule 14 (Fn14) activates mitogen-activated protein kinase (MAPK) signaling and promotes NFκB activation by both canonical and non-canonical pathways. The gene discussed is TNF; the disease is cardiovascular disorder.