Increased PARylation in podocytes has been shown to have a role in glomerular injury associated with type 2 diabetes and general PARP inhibitors ameliorate this pathological situation.29 We found that tankyrases are phosporylated in podocytes and that the absence of CD2AP leads to increased total PARylation due to the activity of tankyrases. Here, PARP1 is linked to type 2 diabetes mellitus.