The glomeruli of cd2ap-MO-treated larvae exhibited disturbed glomerular structures with distended capillary loops (Figure 7f), whereas the cd2ap knockdown larvae treated with XAV939 showed even more disturbed glomerular structures with dilated Bowman's space and proximal convoluted tubules and stretched, septal glomeruli at the midline (Figure 7h) indicating severe kidney damage. The gene discussed is CD2AP; the disease is medical procedure.