In support of this notion, a recent high-throuput sequencing and cross-linking immunoprecipitation (HITS-CLIP) study in K562 leukemia cells have revealed that the direct RNA-binding targets of Msi2 are associated with a variety of pathways involving in RNA metabolism/translation and TGF-β signaling, independently from Numb.37 The targets of Msi2 in osteoclast lineage cells need to be further identified in the future. The gene discussed is NUMB; the disease is leukemia.