SIK2 has been demonstrated to localize in the cytoplasm and peripheral membranes of ER in the interphase of cancer cell lines.37, 39 We further study the subcellular distribution of SIK2 in non-cancer cells (peritoneal mesothelial and foreskin fibroblast Hs68 cells) by biochemical fractionation and immunofluorescence staining. Here, SIK2 is linked to cancer.