Considering the role of aforementioned genesin globozoospermia and in line with our per-vious study (16), the aim of this study was toevaluate the prevalence of missense mutations,G848A, in exon 4 of SPATA16 gene and G198Ain exon 13 of PICK1, as well as DPY19L2 de-letion in Iranian infertile individuals with globozoospermia referring to Isfahan fertility andinfertility center (IFIC). The gene discussed is SPATA16; the disease is Globozoospermia.