GnRH agonist trigger have been shown to be beneficial in situations like repeated IVF failure, empty follicle syndrome and repeated retrieval of immature oocytes, with the hypothesis that some patients may require the FSH surge, in addition to the LH surge, to promote final oocyte maturation resembling the natural midcycle surge of gonadotropins (29,30). The gene discussed is GNRH1; the disease is Empty ovarian follicle.