There have been studies demonstrating that SYNJ2BP possesses a global role in regulating physiological processes such as sprouting angiogenesis, stabilization or localization of transmembrane proteins etc. [36] As angiogenesis plays a part in cancer [19], and in the instance of malignancy, HCC develops a neoplasm and the formation of new vessels is required for its progression [37]. This evidence concerns the gene SYNJ2BP and cancer.