Because there are fewer cytotoxic T-cells with positivity for CD8 in the initial SPTCL lesion, a re-examination of biopsy tissue often exhibits a characteristic picture and histology of SPTCL after the diagnosis of Weber–Christian disease, lupus profundus, or HPS by a histopathological diagnosis in the early stage of the disease. This evidence concerns the gene CD8A and Hermansky-Pudlak syndrome.